全文获取类型
收费全文 | 138篇 |
免费 | 14篇 |
出版年
2021年 | 7篇 |
2020年 | 2篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 6篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 8篇 |
2012年 | 10篇 |
2011年 | 18篇 |
2010年 | 10篇 |
2009年 | 4篇 |
2008年 | 10篇 |
2007年 | 10篇 |
2006年 | 2篇 |
2005年 | 6篇 |
2004年 | 7篇 |
2003年 | 3篇 |
2002年 | 6篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1971年 | 3篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 4篇 |
排序方式: 共有152条查询结果,搜索用时 265 毫秒
151.
A. Schotte P. F. M. Janssen P. Bonaventure J. E. Leysen 《The Histochemical journal》1996,28(11):791-799
Summary [3H]7-hydroxy-N,N-di-n-propyl-2-aminotetralin was used as a radioligand for the autoradiographic measurements of dopamine D3 receptors in rat and human brain. Preincubation of the brain sections was necessary to obtain binding of the radioligand
in the islands of Calleja and in the nucleus accumbens, but not in cerebellar lobules 9/10 of the rat. D3 receptors were also totally occluded in unwashed sections of the human striatum. The radioligand binding to D3 receptors was maximal after preincubating the sections for at least 10 min. Pretreatment of the animals with reserpine or
tetrabenazine, which results in a severe depletion of endogeneous monoamines, strongly reduces the occlusion of D3 receptors in unwashed brain sections. The occlusion of dopamine D3 receptors in brain sections suggests that thein vivo access to D3 receptors may be locally inhibited by endogenous dopamine.
Thein vitro binding affinities of 12 antipsychotic drugs for D2 and D3 receptors were evaluated in competition binding experiments, using both rat and cloned human receptors. Most of the compounds
showed only a slightly lower affinity for D3 than for D2 receptorsin vitro. Affinities of the antipsychotic drugs for cloned human D2L and D3 receptors were very close to their affinities for the rat receptors.In vivo occupancy of these receptors in the rat brain was measuredex vivo by quantitative autoradiography, 2 hours after subcutaneous drug administration. For most compounds, occupancy of D3 receptors, as compared to D2 receptor occupancy, was lower than expected from the correspondingin vivo affinity ratios. For the new antipsychotic risperidone,in vivo occupancy of D3 receptors was measured both in the islands of Calleja and in the cerebellar lobules 9/10. This compound was three times less
potent for the occupancy of D3 receptors in the islands of Calleja than in the cerebellum, an area lacking endogenous dopamine (ED50=28 and 10 mg kg−1, respectively).
Based on the observations in the rat brain, it may reasonably be supposed that therapeutic dosages of antipsychotic drugs
will induce in patients only a minor occupancy of D3 receptors in brain areas containing high dopamine concentrations. The role of dopamine D3 receptors as a target of antipsychotic drugs may therefore be less important than previously thought. 相似文献
152.
Mitriostigma monocaule Sonké & Dessein sp. nov., a new Rubiaceae species from south Cameroon is described and illustrated. The novelty is easily separated from the other four Mitriostigma species by its monocaulous growth form, the other species being shrubs, sub-shrubs, or occasionally trees. Another typical character for the species is its supra-axillary inflorescences paired at the nodes. The novelty is related to M. barteri , from which it further differs in the somewhat larger leaves with a more pronounced acumen and a higher number of secondary veins. A first conservation status for the species is given. A synopsis of the genus Mitriostigma with a taxonomic key is also provided. 相似文献